IACT Staff
As a chemist and biochemist I am fascinated by protein behavior. The high specificity and efficiency in their functions make these macromolecules the most interesting systems in nature from the fundamental and technological point of view. Where these properties lie is the key question to answer. Only two techniques can provide this type of information at a high resolution level, X-ray / Neutron diffraction and electron microscopy. My research is mainly focused on X-ray territory and “surrounding lands”, nucleation and crystal growth.
Projects
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2021
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APLICACIONES BIOTECNOLÓGICAS DE CRISTALES PROTEICOS
Reference: PID2020-116261GB-I00Researcher(s): Jose Antonio Gavira GallardoDate: 1 de September del 2021 - 31 de August del 2024Funding agency: Ministerio
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2018
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BIOSENSORES UNIVERSALES
Reference: BIO2017-91210-EXPResearcher(s): Jose Antonio Gavira GallardoDate: 1 de November del 2018 - 31 de October del 2020Funding agency: Ministerio
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2011
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PRODUCCIÓN Y CARACTERIZACIÓN DE CRISTALES DE PROTEÍNAS REFORZADOS Y ENTRECRUZADOS CON APLICACIONES BIOTECNOLÓGICAS
Reference: BIO2010-16800Researcher(s): Jose Antonio Gavira GallardoDate: 1 de January del 2011 - 31 de March del 2014Funding agency: Ministerio
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Publications
| Authors | Year | Title | Magazine, volume, pages. |
|---|---|---|---|
| Gloria Gamiz-Arco, Luis I. Gutierrez-Rus, Valeria A. Risso, Beatriz Ibarra-Molero, Yosuke Hoshino, Dušan Petrović, Jose Justicia, Juan Manuel Cuerva, Adrian Romero-Rivera, Burckhard Seelig, Jose A. Gavira, Shina C. L. Kamerlin, Eric A. Gaucher, Jose M. Sanchez-Ruiz. | 2021 | Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase | Nature Communications, 12, |
| Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan. | 2021 | Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity | Nature Communications, 12, |
| Tino Krell, José A. Gavira, Félix Velando, Matilde Fernández, Amalia Roca, Elizabet Monteagudo-Cascales, Miguel A. Matilla. | 2021 | Histamine: A Bacterial Signal Molecule | International Journal of Molecular Sciences, 22, 6312 |
| Raquel Fernández-Penas, Cristóbal Verdugo-Escamilla, Sergio Martínez-Rodríguez, José A. Gavira. | 2021 | Production of Cross-Linked Lipase Crystals at a Preparative Scale | Crystal Growth & Design, 21, 1698-1707 |
| Miguel A. Matilla, David Martín-Mora, Jose A. Gavira, Tino Krell. | 2021 | Pseudomonas aeruginosa as a Model To Study Chemosensory Pathway Signaling | Microbiology and Molecular Biology Reviews, 85, |
| José Antonio Gavira, Miguel A. Matilla, Matilde Fernández, Tino Krell. | 2020 | The structural basis for signal promiscuity in a bacterial chemoreceptor | The FEBS Journal, 288, 2294-2310 |
| Albert Castellví, Isidro Crespo, Eva Crosas, Ana Cámara-Artigas, José A. Gavira, Miguel A. G. Aranda, Xavier Parés, Jaume Farrés, Judith Juanhuix. | 2019 | Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation | Scientific Reports, 9, |
| David Martín-Mora, Álvaro Ortega, Miguel A. Matilla, Sergio Martínez-Rodríguez, José A. Gavira, Tino Krell. | 2019 | The Molecular Mechanism of Nitrate Chemotaxis via Direct Ligand Binding to the PilJ Domain of McpN | mBio, 10, |
| José Antonio Gavira, Álvaro Ortega, David Martín-Mora, María Teresa Conejero-Muriel, Andrés Corral-Lugo, Bertrand Morel, Miguel A. Matilla, Tino Krell. | 2018 | Structural Basis for Polyamine Binding at the dCACHE Domain of the McpU Chemoreceptor from Pseudomonas putida | Journal of Molecular Biology, 430, 1950-1963 |
PhD Thesis
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2016
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Cristalización de proteínas en hidrogeles péptidos diseñados ad hoc para proteger los cristales frente al daño por radiación-X
Type: Trabajo Fin de MásterDate: 12/07/2016Autores/as de tesis: Guillermo Escolano Casado.Directores/as de tesis: Jose Antonio Gavira Gallardo.UNED -
Síntesis y caracterización de cristales de lipasas entrecruzados. Aplicaciones en procesos de catálisis
Type: Trabajo Fin de MásterDate: 11/07/2016Autores/as de tesis: Raquel Fernández Penas.Directores/as de tesis: Jose Antonio Gavira Gallardo.FUNDACION GENERAL DE LA UNED (FUNED)
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2012
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Proteínas ancestrales: reconstruccion y caracterización energética, funcional y estructural
Type: Tesis DoctoralDate: 19/12/2012Autores/as de tesis: Alvaro Ingles Prieto.Directores/as de tesis: Jose Antonio Gavira Gallardo.UNIVERSIDAD DE GRANADA -
Production, characterization and crystallization of the prokaryotic membrane coat protein 4978: evolutionary implications on the eukaryogenesis process
Type: Tesis DoctoralDate: 19/07/2012Autores/as de tesis: Mª Teresa Conejero Muriel.Directores/as de tesis: Jose Antonio Gavira Gallardo, Maria Estela Pineda Molina.UIMP-CSIC
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Knowledge transfer
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2016
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Pharmaceutically active protein crystals grown in-situ within a hydrogel
Date: 05/05/2016Reference: P201630584Institution: UGR-CSICNaturaleza: Patente nacionalAuthor: Luis Alvarez de Cienfuegos, José A. Gavira, Juan J Díaz-Mochón, Mayte Conejero-Muriel, Rafael Contreras-Montoya
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2014
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Sistema optofluídico para reacciones biocatalíticas con cristales de enzimas entrecruzados
Date: 22/01/2014Reference: ES 2 541 623 A1Institution: CSICAuthor: Isaac Rodríguez-Ruiz, José Antonio Gavira Gallardo, Andreu Llobera Adán, Juan Manuel García Ruiz, Jaime Gómez Morales
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2013
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Sistemas optofluídicos y su aplicación en estudios de cristalización de moléculas pequeñas
Date: 25/10/2013Reference: 201331570Institution: CSICAuthor: Isaac Rodríguez-Ruiz, Andreu Llobera Adán, Juan Manuel García Ruiz, Jaime Gómez Morales
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2006
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Through-Put Crystallization Cassette for the Growth and Optimization of Macromolecular Crystals
Date: 10/10/2006Reference: 7.118.626Institution: MSFC (MFS-31948)Author: Ng, J.D., García-Ruiz, J.M., Gavira-Gallardo, J.A., Well M., Greg J.
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